DHR1 domain

DHR1 (DOCK homology region 1), also known as CZH1 or Docker1, is a protein domain of approximately 200-250 amino acids that is present in the DOCK family of signalling proteins.[1] This domain binds phospholipids and so may assist in recruitment to cellular membranes.[2] There is evidence that this domain may also mediate protein-protein interactions.[3]

References

  1. ^ Meller N, Merlot S, Guda C (November 2005). "CZH proteins: a new family of Rho-GEFs". J. Cell Sci. 118 (Pt 21): 4937–46. doi:10.1242/jcs.02671. PMID 16254241. 
  2. ^ Côté JF, Motoyama AB, Bush JA, Vuori K (August 2005). "A novel and evolutionarily conserved PtdIns(3,4,5)P3-binding domain is necessary for DOCK180 signalling". Nat. Cell Biol. 7 (8): 797–807. doi:10.1038/ncb1280. PMC 1352170. PMID 16025104. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1352170. 
  3. ^ Hara S, Kiyokawa E, Iemura SI et al. (July 2008). "The DHR1 Domain of DOCK180 Binds to SNX5 and Regulates Cation-independent Mannose 6-phosphate Receptor Transport". Mol. Biol. Cell (Article in press) (9): 3823–35. doi:10.1091/mbc.E08-03-0314. PMC 2526700. PMID 18596235. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2526700. 

Further reading